Container closure integrity testing can be implemented either directly within the production line or in dedicated laboratory environments. Inline testing allows manufacturers to monitor packaging integrity continuously during manufacturing, quickly identifying defects before products proceed further in the process. Offline testing, on the other hand, provides greater flexibility and is often used during research, validation, and stability studies. Each approach offers distinct advantages depending on the testing objectives. Many pharmaceutical manufacturers combine both strategies to create a comprehensive inspection program that ensures packaging reliability and product safety.